Clinical Management Tools

General Interference with Clinical Chemistry Laboratory Analyses: 


  • Our product’s intense coloration can interfere with some laboratory tests that are based on colorimetric, or optical, methodologies.
  • Assays based on protein measurements will also be affected.
  • The degree of interference depends on the dose, the analyte, and the instrument.
  • A ‘hemolytic index’ may flag results above a set range because hemolysis in a sample can indicate sample contamination.  This may not be reflective of a particular assay’s ability to measure in the presence of our product.
  • The interferences lessen as our product is cleared, with a half-life of about 19 hours. All tests should be available within 4 days after the last infusion of our product.


Exact interference levels vary from one instrument type to another. Tables 1-3 represent conservative guidelines by analyte after testing a wide variety of analyzers in different labs and reporting only tests that all instruments could measure. Particular instruments will have higher limits.


Table 1. Clinical Lab Tests that have been found to be GENERALLY ACCURATE for all analyzers tested.

Laboratory Results




BUN, Calcium, Ionized Calcium, Chloride, CK-MB, Creatinine, Glucose, Potassium, Sodium

  • tested to 6.5 g/dL HBOC in plasma


Table 2.   Clinical Lab Tests that have been found to be GENERALLY ACCURATE to 1 g/dL of our product in plasma for all analyzers tested.  Some instruments can be accurate at higher doses.


Laboratory Results


ACCURATE to 1 g/dL of our product in plasma.  Accuracy decreases after that.

Cholesterol, CRP, lactate, LDH, lipase, Magnesium ,Troponin I, Troponin T


Table 3.   Clinical Lab Tests that have been found to be GENERALLY NEVER ACCURATE for all analyzers tested.   There are exceptions.


Laboratory Results



NEVER ACCURATE in presence of our product.

Albumin, Alkaline Phosphatase, ALT, Amylase, AST, Bilirubin, GGT, LDH, Phosphorous, Total Protein, Uric Acid



Laboratory Interference Reference Guide

For individuals interested in the impact of hemoglobin based oxygen carriers on laboratory assays.

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