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Oxyglobin Solution Product Attributes

Readily Available

Oxyglobin is readily available and requires no preparation prior to use because it is:

  • Stable at room temperature (2° to 30° C) for three years from date of manufacture and does not require refrigeration, warming or reconstitution;
  • Compatible with all blood types, and does not require blood typing, testing or cross-matching; and
  • Ultra-purified through a patented, validated process to remove potential contaminants, including infectious agents (e.g. viruses, bacteria, TSE agents).

Carries Oxygen

A commitment was made to develop an oxygen therapeutic for veterinary use when early preclinical studies showed positive results in multiple animal species. To date, more than 200 reclinical studies have been conducted or sponsored. This body of data suggests that Oxyglobin transports oxygen to tissues more efficiently than red blood cells and increases the oxygen-carrying efficiency of circulating red blood cells.

  • Oxyglobin transports oxygen immediately upon administration and under ambient conditions (i.e., works with room air, and does not require an oxygen mask).
  • Preclinical data have shown that Oxyglobin molecules are three times more efficient than natural red blood cells in their ability to oxygenate tissues.
  • In vitro studies suggest that Oxyglobin molecules further facilitate oxygen transport by increasing the loading of oxygen to red blood cells in the lungs and by improving oxygen off-loading from red blood cells to tissues.

Effectiveness

Results from a pivotal multi-center clinical trial of 64 anemic dogs showed a 95 percent efficacy rate in those treated with Oxyglobin compared with 32 percent in the control group, which received cage rest. Oxyglobin-treated dogs also had significantly increased plasma hemoglobin concentrations (more oxygen in the plasma) and a significantly improved physical condition as measured by heart rate, attitude and physical activity compared to pre-treatment.

Safety

In the clinical trial, the most commonly reported adverse reactions in dogs were a transient discoloration of sclera and urine, vomiting, and over-expanded vascular volume when administered at a higher than recommended rate. Less frequent adverse events that may or may not have been related to the administration of Oxyglobin included diarrhea, fever, arrhythmia (irregular heart rhythm) and tachypnea (rapid rate of breathing).



Last Update: November 2011

Laboratory Interference Reference Guide

For individuals interested in the impact of hemoglobin based oxygen carriers on laboratory assays.

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Oxyglobin® Solution Use Video

View an Oxyglobin® Solution video case study of a dog with thrombocytopenia and IMHA being administered Oxyglobin.